GCKR Variants Increase Triglycerides While Protecting from Insulin Resistance in Chinese Children
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چکیده
منابع مشابه
GCKR Variants Increase Triglycerides While Protecting from Insulin Resistance in Chinese Children
BACKGROUND Variants in gene encoding glucokinase regulator protein (GCKR) were found to have converse effects on triglycerides and glucose metabolic traits. We aimed to investigate the influence of GCKR variants for triglycerides and glucose metabolic traits in Chinese children and adults. METHODS AND RESULTS We genotyped two GCKR variants rs1260326 and rs1260333 in children and adults, and a...
متن کاملEffects of Genetic Variants in ADCY5, GIPR, GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children
OBJECTIVE Recent genome-wide association studies identified novel candidate genes for fasting and 2 h blood glucose and insulin levels in adults. We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children. RESEARCH DESIGN AND METHODS We genotyped four variants (rs2877716; rs1260326; rs10423928; rs17271305) in...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0055350